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Meanings and definitions for PFO

Patent foramen ovale - a blood-flow pathway between a human heart's atriums, normally naturally closed after birth
Personal Freedom Outreach - an Evangelical organization opposing cults
Pittsburgh Film Office
IATA code for Paphos International Airport
Pathfinder Roleplaying Game - online version
Persistent Felony Offender - a defendant accused under a three-strikes law
Hong Kong's Public Finance Ordinance.
International airport (code), Cyprus
Polite Fuck Off, or Please Fuck Off